March 21, 2010 / Energy Substrates, Epilepsy, Excitatory GABA, Lactate, Neuroprotectors, Pyruvate
In the previous post On the mechanisms of brain protection by ketones, I described how a shortage of ketones caused pathological changes in brain cells in brain slices (in vitro, 1) and in whole ani
March 17, 2010 / Ketone bodies, Methodology
D-beta-Hydroxybutyrate is a physiologically occurring D-isomer produced by hepatocytes and, to a lesser extent, by astrocytes. It is an alternative source of energy in the brain when glucose suppl
March 17, 2010 / Brain metabolism, Theories
Read when and why glycolysis is harmful --> click here The choice of an energy pathway is dictated by the law of substrate along-term avilability in food The utilization of an energy source depen
March 17, 2010 / Neuroprotectors, Pyruvate
Pyruvate is one of major energy carriers in the brain, it is shown to be protective against damaging consequences of neurotoxins, such as hydrogen peroxide, glutamate, zinc, and copper/cysteine (1). P
March 17, 2010 / Dementia, Excitatory GABA, Ketogenic diet, Ketone bodies, Neuroprotectors
Neuronal activity in immature neocortical neurons depends on the availability of ketone bodies in ACSF [caption id="" align="alignleft" width="120" caption="The provoking findings of Rheims et al. su
March 17, 2010 / Energy Homeostasis, The selfish brain, Theories
The unique position of the brain as a body organ is characterized by: 1. its chemical isolation from the rest of the body by the blood-bran barrier 2. its high energy consumption: though weighing
March 1, 2010 / Brain metabolism, Glucose, Ketone bodies