Both hypervitaminosis D3 and hypovitaminosis D3 cause premature aging of CNS
Vitamin D3 is not a vitamin because it is not biologically active as it is. However, the body’s hormonal system cannot function properly without it since the body has to be helped with proper diet and sun light. The tree hormones are called calcipherols and they are fully dependent on Vit. D3, they are: calcidiol, calcitriol and 24-calcitriol. The brain is capable of synthesizing the calcipherol hormones and has Vitamin D3 receptors in the cortex, cerebellum, mesopontine area, diencephalon, spinal cord, amygdala, hypothalamus and hippocampus.
Calcipherol hormones are involved in the control of anxiety, autism, seasonal affective disorder, schizophrenia, Parkinson’s and Alzheimer’s diseases, and reducing risk of multiple sclerosis. Hypovitaminosis D3 may cause a premature aging of cognitive functions.
As people age, their calcipherol endocrine system becomes vulnerable. The production of calcipherols by the skin decreases partly because elderly people are less exposed to sunlight. Somewhat of a paradox,, the calcipherol hormone seems to enhance aging. The appearance of prematurely aging mice with hypovitaminosis are similar to those of hypervitaminosis D3. However, the precise role of calcipherol hormones in the brain aging remains to be studied.
Source: Psychoneuroendocrinology (2009) 34S, S278—S286