pH, GDP, energy substrates…
1. “The suppression of GDPs was strictly proportional to the fall in pH(i) caused by weak carboxylic acids (l-lactate, d-lactate, or propionate)”
Source:Spontaneous Network Events Driven by Depolarizing GABA Action in Neonatal Hippocampal Slices are Not Attributable to Deficient Mitochondrial Energy Metabolism. Ruusuvuori E, Kirilkin I, Pandya N, Kaila K. J Neurosci. 2010 Nov 17;30(46)
2. ”We show that a spontaneous network activity pattern, giant depolarizing potentials (GDPs), characteristic for the neonatal hippocampal slices exposed to artificial cerebrospinal fluid, is strongly inhibited by complementary energy substrates and this effect is unlikely to be caused by a subtle intracellular acidification induced by these compounds”
Source:Inhibition of spontaneous network activity in neonatal hippocampal slices by energy substrates is not correlated with intracellular acidification. Mukhtarov M, Ivanov A, Zilberter Y, Bregestovski P. J Neurochem. 2011 Jan;116(2):316-21.