May 8, 2012 / Astrocyte–neuron lactate shuttle, Energy Substrates, Lactate, Neuroscience FAQ, Q&A
Q&A and FAQ (archived) :: Ongoing Q&A :: Neuroscience Q&A and FAQ Question Hi: I've heard the brain uses lactate [which it obtains from glucose] for energy. Does this mean the
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November 30, 2011 / Alzheimer's, Glucose, Ketone bodies, Lactate
Chronic exposure to glucose due to the traditional Western diet impairs neuronal function and causes apoptosis (programmed neuronal death), concluded Drs Seneff & Wainwright (UK) and Mas
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November 17, 2011 / Brain metabolism, Energy Substrates, Ethics in science, Excitatory GABA, Lactate, Methodology, Neurodegenerative diseases, Neuroscience FAQ, Q&A
Related Q&A: "Y Ben-Ari writes that 'Zilberter and Bregestovski and colleagues' dealt with 'ketone body metabolites'. What does ketone body metabolite mean? " About this post 1. These quotes
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July 4, 2011 / Ethics in science, Ketosis, ketogenesis, Lactate, Neuroscience FAQ, Q&A
Q&A and FAQ (archived) :: Ongoing Q&A :: Neuroscience Q&A and FAQ Question: Hi Tanya, I am fascinated by development at the Faculty of 1000 started by Y. Ben-Ari. I couldn't contain
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June 9, 2011 / Excitatory GABA, Ketone bodies, Lactate, Methodology, Pyruvate
Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? What concentrations are physiolog
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June 4, 2011 / Brain metabolism, Energy Substrates, Excitatory GABA, Glucose, Ketone bodies, Lactate, Pyruvate
Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? [caption id="" align="alignleft"
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May 23, 2011 / Astrocyte–neuron lactate shuttle, Lactate
In the Journal club section of the Journal of Neuroscience (written exclusively by graduate students or postdoctoral fellows), a review by C. Figley from Johns Hopkins University and Kennedy Krieger I
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May 7, 2011 / Applications, Energy Substrates, Glucose, Ketone bodies, Lactate, Pyruvate
Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? Is glucose the absolutely exclus
November 15, 2010 / Epilepsy, Glucose, Ketone bodies, Lactate, Neuroprotectors, Pyruvate
A few interesting articles about glucose, lactate, and pyruvate and their neuroprotective functions. J Neurochem. 2010 Feb 15 Chronic in vitro ketosis is neuroprotective but not anticonvulsant. Ma
October 4, 2010 / Astrocyte–neuron lactate shuttle, Lactate, Neuroscience FAQ, Q&A
Original Q&A :: About these Q&A :: Other Q&A Q: Dr. Zilberter, I am a little bit confused in the area of what they call shuttles between neurons and glial cells. What the suttles do?
July 31, 2010 / Astrocyte–neuron lactate shuttle, Lactate, Methodology
Glucose is an energy source for both neurons and glia in the adult brain but lactate, one of the monocarboxylic acids, being converted from pyruvate in astrocytes and supplied to neuron ("astrocyte-ne
June 13, 2010 / Astrocyte–neuron lactate shuttle, Glucose, Lactate
Updates: Glucose versus lactate in immature brain slices Brain metabolism updates: Sweet and sour recipes for the brain Astrocyte-neuron lactate transport is required for long-term memory formation
March 21, 2010 / Energy Substrates, Epilepsy, Excitatory GABA, Lactate, Neuroprotectors, Pyruvate
In the previous post On the mechanisms of brain protection by ketones, I described how a shortage of ketones caused pathological changes in brain cells in brain slices (in vitro, 1) and in whole ani
February 17, 2010 / Energy Substrates, Glucose, Ketone bodies, Lactate
The use of energy substrates by the brain depend on species, age, and physiological conditions
February 17, 2010 / Energy Homeostasis, Ketone bodies, Lactate, Pyruvate
In addition to glucose, other substrates must be considered along with fuel interactions, metabolic challenges, and cerebral maturation. (1) Ketone bodies are major metabolic fuels of the brain o