July 9, 2011 / Alzheimer's, Neuroscience FAQ, Q&A, Parkinson's, Pyruvate
Q&A and FAQ (archived) :: Ongoing Q&A :: Neuroscience Q&A and FAQ Question I've read on WebMD that there's no evidence that anything can be done to fight off Alzheimer's disease. But I
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June 9, 2011 / Excitatory GABA, Ketone bodies, Lactate, Methodology, Pyruvate
Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? What concentrations are physiolog
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June 4, 2011 / Brain metabolism, Energy Substrates, Excitatory GABA, Glucose, Ketone bodies, Lactate, Pyruvate
Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? [caption id="" align="alignleft"
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May 7, 2011 / Applications, Energy Substrates, Glucose, Ketone bodies, Lactate, Pyruvate
Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? Is glucose the absolutely exclus
November 16, 2010 / Excitatory GABA, Glucose, Ketone bodies, Methodology, Pyruvate
“They teach us in our institutes that GABA is excitatory in the neonates, should we still believe it?" (Excitatory GABA scandal?) There was an interesting development in the Department of Neur
November 15, 2010 / Epilepsy, Glucose, Ketone bodies, Lactate, Neuroprotectors, Pyruvate
A few interesting articles about glucose, lactate, and pyruvate and their neuroprotective functions. J Neurochem. 2010 Feb 15 Chronic in vitro ketosis is neuroprotective but not anticonvulsant. Ma
March 21, 2010 / Energy Substrates, Epilepsy, Excitatory GABA, Lactate, Neuroprotectors, Pyruvate
In the previous post On the mechanisms of brain protection by ketones, I described how a shortage of ketones caused pathological changes in brain cells in brain slices (in vitro, 1) and in whole ani
March 17, 2010 / Neuroprotectors, Pyruvate
Pyruvate is one of major energy carriers in the brain, it is shown to be protective against damaging consequences of neurotoxins, such as hydrogen peroxide, glutamate, zinc, and copper/cysteine (1). P
February 17, 2010 / Energy Homeostasis, Ketone bodies, Lactate, Pyruvate
In addition to glucose, other substrates must be considered along with fuel interactions, metabolic challenges, and cerebral maturation. (1) Ketone bodies are major metabolic fuels of the brain o