Archive for the Methodology Category

January 6, 2012 / Brain metabolism, Energy Substrates, Methodology

Sweet and sour recipes for the brain. 3. Let the neurons breathe!

Latest update: Critical State of Energy Metabolism in Brain Slices: The Principal Role of Oxygen Delivery and Energy Substrates in Shaping Neuronal Activity  Part 1. "Sweet slices are fine"?

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December 1, 2011 / Glucose, Ketogenic diet, Ketone bodies, Ketosis, ketogenesis, Methodology

The basics of ketogenic diet: works of Shaffer and Wilder & Winter

It is interesting that while the ketogenic diet becomes well researched as a method for improving energy metabolism during quite a few medical conditions and the number of original research articles

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November 17, 2011 / Brain metabolism, Energy Substrates, Ethics in science, Excitatory GABA, Lactate, Methodology, Neurodegenerative diseases, Neuroscience FAQ, Q&A

Glucose versus lactate in immature brain slices

Glucose versus lactate in immature brain slices

Related Q&A: "Y Ben-Ari writes that 'Zilberter and Bregestovski and colleagues' dealt with 'ketone body metabolites'. What does ketone body metabolite mean? " About this post 1. These quotes

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June 9, 2011 / Excitatory GABA, Ketone bodies, Lactate, Methodology, Pyruvate

Sweet and sour recipes for the brain 4. “Physiological” concentrations: what and where?

Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? What concentrations are physiolog

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April 13, 2011 / Methodology, Theories of Mind

Placebo: a medicine created by the mind

The word placebo initially meant "I will please": "Placebo Domino in regione vivorum" ("I shall please the Lord in the land of the living," referring to the Latin translation of the Bible by Jerome,

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February 1, 2011 / Methodology, Theories of Mind

Mirror neurons, autism, and the theory of mind

Related: Schrödinger’s One Mind :: Non-local mind bibliography The theory of mind presumes that we can only imagine that others have a mind because we have no direct access to the mind of anothe

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November 21, 2010 / Brain metabolism, Energy Substrates, Methodology

pH, GDP, energy substrates…

1. "The suppression of GDPs was strictly proportional to the fall in pH(i) caused by weak carboxylic acids (l-lactate, d-lactate, or propionate)" Source: Spontaneous Network Events Driven by Depol

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November 16, 2010 / Excitatory GABA, Glucose, Ketone bodies, Methodology, Pyruvate

Great Controversies in Neurobiogy

“They teach us in our institutes that GABA is excitatory in the neonates, should we still believe it?" (Excitatory GABA scandal?) There was an interesting development in the Department of Neur

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September 20, 2010 / Excitatory GABA, Methodology, Neuroscience FAQ, Q&A

How does GABA behave in the intact brain?

Original Q&A :: About these Q&A :: Other Q&A Q: Dr. Zilberter, In your post at brainfuels.com, you cited several researchers and the closing phrase was: "The work undermined the role

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August 19, 2010 / Methodology, Theories

Books by Alexander Luria in English

A.R. Luria was one of the most significant psychological researchers and theorists of the 20th century. He is considered to have founded the field of neuropsychology, and he had a great influence on a

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July 31, 2010 / Astrocyte–neuron lactate shuttle, Lactate, Methodology

Comparison of lactate kinetics in vitro and in vivo is to be done

Glucose is an energy source for both neurons and glia in the adult brain but lactate, one of the monocarboxylic acids, being converted from pyruvate in astrocytes and supplied to neuron ("astrocyte-ne

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July 19, 2010 / Energy Homeostasis, Energy Substrates, Excitatory GABA, Methodology

Neuronal activity in vitro and the in vivo reality

In the brain, neuronal electrical activity and intricate metabolic energy provisions are closely related. Although both functions have been painstakingly researched by electrophysiologists and biochem

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July 12, 2010 / Methodology

Barriers and fluids that connect and divide blood, brain, and neurons

BRAIN EXTRACELLULAR FLUID Read also: The History of Artificial Cerebrospinal Fluid (ACSF) The brain is protected by a rigid bony case so it cannot expand in the case of fluid imbalance. Because of

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June 19, 2010 / Astrocyte–neuron ketone shuttle, Astrocyte–neuron lactate shuttle, Energy Homeostasis, Energy Substrates, Excitatory GABA, Methodology

Studies of GABA action: in vivo, in toto, and in vitro

On discrepancies of data from experiments on brain slices, in toto, and in vivo Let's start with the fundamental differences between environments depending on the types of experiments. (See Commenta

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May 22, 2010 / Methodology

The History of Artificial Cerebrospinal Fluid (ACSF)

  For the ACSF updates in 2009 to 2011 -> see Sweet & sour recipes for the brain  ACSF from 1934 to 1950.       Events     Comments  

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