November 26, 2011 / Epilepsy, Neuroprotectors
Epilepsy is thought to be associated with oxidative stress, which play its role in the seizures-induced neuronal death (1, 2). On the other hand, the brain, due to a high content of polyunsaturated fa
April 9, 2011 / Neurodegenerative diseases, Neuroprotectors
Related: Is Q10 a fitness-enhancing or an anti-aging supplement in the long run? "Several clinical trials of CoQ10 have been performed in Parkinson’s disease and atypical Parkinson’s syndromes,
February 20, 2011 / Alzheimer's, Neurodegenerative diseases, Neuroprotectors
Related: Resveratrol and curcumin, plant’s own weapons that protect the brain 1. Curcumin is a better antioxidant than alpha-tocopherol and can protect blood vessel cells from oxidative stress cau
January 18, 2011 / Dementia, Epilepsy, Neuroprotectors, Parkinson's
The study conducted by researchers at McGill University in Montreal and published in January 2011 issue of Nature Neuroscience showed that the music increased dopamine levels in certain areas of t
November 27, 2010 / Energy Homeostasis, Energy Substrates, Glucose, Ketone bodies, Neuroprotectors
Medium-Chain Fatty Acids Improve Cognitive Function and Support In Vitro Synaptic Transmission During Acute Hypoglycemia (1) The brain can use alternative fuels such as monocarboxylic acids, lactat
November 15, 2010 / Epilepsy, Glucose, Ketone bodies, Lactate, Neuroprotectors, Pyruvate
A few interesting articles about glucose, lactate, and pyruvate and their neuroprotective functions. J Neurochem. 2010 Feb 15 Chronic in vitro ketosis is neuroprotective but not anticonvulsant. Ma
October 15, 2010 / Brain metabolism, Dementia, Energy Substrates, Neuroprotectors
Twenty-five percent of individuals over 65 years of age have sufficient cognitive problems, short of dementia, to affect the quality of their lives (1, 2). The ability to learn consciously and recall
August 30, 2010 / Alzheimer's, Dementia, Neurodegenerative diseases, Neuroprotectors, Parkinson's
“Thinking, Moving, Feeling”: What Do They Have in Common? This question opens a review of age-related declines, their inter-relationships, mechanisms, and the ways to postpone if not avoid th
August 25, 2010 / Ketone bodies, Neuroprotectors
There are seven traits allowing ketones to serve as neuroprotectors during brain damage: they require only three steps to enter the Krebs cycle (footnote a) - compare with 9 steps obligatory f
June 9, 2010 / Brain metabolism, Neuroprotectors, Parkinson's
Both hypervitaminosis D3 and hypovitaminosis D3 cause premature aging Vitamin D3 is not a vitamin because it is not biologically active as it is. However, without it, the body's hormonal system cant
April 17, 2010 / Energy Substrates, Excitatory GABA, Methodology, Neuroprotectors, Theories
As described in the post "On the mechanisms of brain protection by ketones", GABA, the principal brain chemical, normally acts to prevent hyperactivity in the neuronal networks. However, in the imma
March 21, 2010 / Energy Substrates, Epilepsy, Excitatory GABA, Lactate, Neuroprotectors, Pyruvate
In the previous post On the mechanisms of brain protection by ketones, I described how a shortage of ketones caused pathological changes in brain cells in brain slices (in vitro, 1) and in whole ani
March 17, 2010 / Neuroprotectors, Pyruvate
Pyruvate is one of major energy carriers in the brain, it is shown to be protective against damaging consequences of neurotoxins, such as hydrogen peroxide, glutamate, zinc, and copper/cysteine (1). P
March 17, 2010 / Dementia, Excitatory GABA, Ketogenic diet, Ketone bodies, Neuroprotectors
Neuronal activity in immature neocortical neurons depends on the availability of ketone bodies in ACSF [caption id="" align="alignleft" width="120" caption="The provoking findings of Rheims et al. su