November 17, 2011 / Brain metabolism, Energy Substrates, Ethics in science, Excitatory GABA, Lactate, Methodology, Neurodegenerative diseases, Neuroscience FAQ, Q&A
Related Q&A: "Y Ben-Ari writes that 'Zilberter and Bregestovski and colleagues' dealt with 'ketone body metabolites'. What does ketone body metabolite mean? " About this post 1. These quotes
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June 9, 2011 / Excitatory GABA, Ketone bodies, Lactate, Methodology, Pyruvate
Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? What concentrations are physiolog
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June 4, 2011 / Brain metabolism, Energy Substrates, Excitatory GABA, Glucose, Ketone bodies, Lactate, Pyruvate
Part 1. "Sweet slices are fine"? Part 2. Energy substrates: too sour? Part 3. Let the neurons breathe! Part 4. "Physiological" concentrations: what and where? [caption id="" align="alignleft"
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November 22, 2010 / Energy Substrates, Excitatory GABA
The Epilepsy Currents journal, Volume 10, Issue 5, pages 128–130, September/October 2010, published an article titled "Another Look at Early GABAergic Neurotransmission: Maybe It's Not So Excitin
November 16, 2010 / Excitatory GABA, Glucose, Ketone bodies, Methodology, Pyruvate
“They teach us in our institutes that GABA is excitatory in the neonates, should we still believe it?" (Excitatory GABA scandal?) There was an interesting development in the Department of Neur
September 20, 2010 / Excitatory GABA, Methodology, Neuroscience FAQ, Q&A
Original Q&A :: About these Q&A :: Other Q&A Q: Dr. Zilberter, In your post at brainfuels.com, you cited several researchers and the closing phrase was: "The work undermined the role
July 19, 2010 / Energy Homeostasis, Energy Substrates, Excitatory GABA, Methodology
In the brain, neuronal electrical activity and intricate metabolic energy provisions are closely related. Although both functions have been painstakingly researched by electrophysiologists and biochem
June 19, 2010 / Astrocyte–neuron ketone shuttle, Astrocyte–neuron lactate shuttle, Energy Homeostasis, Energy Substrates, Excitatory GABA, Methodology
On discrepancies of data from experiments on brain slices, in toto, and in vivo Let's start with the fundamental differences between environments depending on the types of experiments. (See Commenta
April 17, 2010 / Energy Substrates, Excitatory GABA, Methodology, Neuroprotectors, Theories
As described in the post "On the mechanisms of brain protection by ketones", GABA, the principal brain chemical, normally acts to prevent hyperactivity in the neuronal networks. However, in the imma
March 21, 2010 / Energy Substrates, Epilepsy, Excitatory GABA, Lactate, Neuroprotectors, Pyruvate
In the previous post On the mechanisms of brain protection by ketones, I described how a shortage of ketones caused pathological changes in brain cells in brain slices (in vitro, 1) and in whole ani
March 17, 2010 / Dementia, Excitatory GABA, Ketogenic diet, Ketone bodies, Neuroprotectors
Neuronal activity in immature neocortical neurons depends on the availability of ketone bodies in ACSF [caption id="" align="alignleft" width="120" caption="The provoking findings of Rheims et al. su