Brain
slices: the dead end?
Original Q&A
Q: Dr Zilberter,
I just noticed that your review article is published (at least online) and here are my 3 questions:
1. How can I get a PDF of this review?
2. From your braifuels.com's tidbits, I understood that the slice technique is under fire. Is this because it's impossible to adequately provide for neuron's life and work or just because nobody really cared until recently (the "GABA scandal" Q&A is such an interesting reading!)
3. Since there's an in vivo result showing that GABA is actually always inhibitory, what remains of the theory of excitatory GABA?
I am very excited to witness an interesting turn of one of textbooks' dogmas!
Dollie
A: Dear Dollie,
1. Please contact me from brainfuels.com's regarding the PDF of our review. Read the abstract here
2. I hope your second question will be answered after you get the full text. Meanwhile, if you read the History of aCSF - you'll notice that this history stopped 60 years ago. Why? Some of the explanation can be found here: Neuronal activity in vitro and the in vivo reality
3. I guess you mean the "four situations with GABA action" specifically, the only so far known experiment showing how GABA behaves in reality. Yes, this is a strong argument against the textbook dogma you've mentioned, imho; Studies of GABA action: in vivo, in toto, and in vitro.
Thank you for your interesting thoughts,
Tanya Zilberter
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