July 19, 2010 / Energy Homeostasis, Energy Substrates, Excitatory GABA, Methodology
In the brain, neuronal electrical activity and intricate metabolic energy provisions are closely related. Although both functions have been painstakingly researched by electrophysiologists and biochem
March 21, 2010 / Energy Substrates, Epilepsy, Excitatory GABA, Lactate, Neuroprotectors, Pyruvate
In the previous post On the mechanisms of brain protection by ketones, I described how a shortage of ketones caused pathological changes in brain cells in brain slices (in vitro, 1) and in whole ani
March 17, 2010 / Dementia, Excitatory GABA, Ketogenic diet, Ketone bodies, Neuroprotectors
Neuronal activity in immature neocortical neurons depends on the availability of ketone bodies in ACSF [caption id="" align="alignleft" width="120" caption="The provoking findings of Rheims et al. su
February 17, 2010 / Applications, Ketogenic diet, Ketone bodies
February 17, 2010 / Ketogenic diet, Ketone bodies, Theories
HYPOTHESES: Ketogenic diet reduces seizures by: a) promoting inhibitory action of GABA b) reducing cellular consequences of energy deficiency by supplying an alternative and 40 % more effici