Both hypervitaminosis D3 and hypovitaminosis D3 cause premature aging of CNS

Brain metabolism,Neuroprotectors,Parkinson's — Tags: , , , , , , , , , , — 7:37 am
Both hypervitaminosis D3 and hypovitaminosis D3 cause premature aging
Vitamin D3 is not a vitamin because it is not biologically active as it is. However, without it, the body’s hormonal system cant function properly without the vitamin, which is not produced by the body so the body has to be helped with proper diet and sun light. The tree hormones are called calcipherols and they are fully dependent on Vit. D3, they  are: calcidiol, calcitriol and 24-calcitriol. The brain is capable of synthesizing the calcipherol hormones and has Vitamin D3 receptors in the cortex, cerebellum, mesopontine area, diencephalon, spinal cord, amygdala, hypothalamus and hippocampus.
Calcipherol hormones are involved in the control of anxiety, autism, seasonal affective disorder, schizophrenia, Parkinson’s and Alzheimer’s diseases, and reducing risk of multiple sclerosis. Hypovitaminosis D3 may cause a premature aging of cognitive functions.
As people age, their calcipherol endocrine system becomes vulnerable. The production of calcipherols by the skin decreases partly because elderly people are less exposed to sunlight. Somewhat of a paradox,, the calcipherol hormone seems to enhance aging. The appearance of prematurely aging mice with hypovitaminosis are similar to those of hypervitaminosis D3. However, the precise role of calcipherol hormones in the brain aging remains to be studied.
Source: Psychoneuroendocrinology (2009) 34S, S278—S286

Related post: Vitamin D and mental health – an easy solution for serious problems?

Vitamin D3 is not a vitamin because it is not biologically active as it is. However, the body’s hormonal system cannot function properly without it since the body has to be helped with proper diet and sun light. The tree hormones are called calcipherols and they are fully dependent on Vit. D3, they  are: calcidiol, calcitriol and 24-calcitriol. The brain is capable of synthesizing the calcipherol hormones and has Vitamin D3 receptors in the cortex, cerebellum, mesopontine area, diencephalon, spinal cord, amygdala, hypothalamus and hippocampus.

Calcipherol hormones are involved in the control of anxiety, autism, seasonal affective disorder, schizophrenia, Parkinson’s and Alzheimer’s diseases, and reducing risk of multiple sclerosis. Hypovitaminosis D3 may cause a premature aging of cognitive functions.

As people age, their calcipherol endocrine system becomes vulnerable. The production of calcipherols by the skin decreases partly because elderly people are less exposed to sunlight. Somewhat of a paradox,, the calcipherol hormone seems to enhance aging. The appearance of prematurely aging mice with hypovitaminosis are similar to those of hypervitaminosis D3. However, the precise role of calcipherol hormones in the brain aging remains to be studied.

Source: Psychoneuroendocrinology (2009) 34S, S278—S286

The Selfish Brain Theory

Energy Homeostasis,The selfish brain,Theories — Tags: , , , , , — 7:55 am

The unique position of the brain as a body organ is characterized by:

1. its chemical isolation from the rest of the body by the blood-bran barrier
2. its high energy consumption: though weighing as little as 2% of the body mass the brain consumes above 20% of all available energy
3. its low energy depot capacity,
4. its energy substrate selectivity,
5. its plasticity – ability to adjust reactions to circumstances and learn how to anticipate the consequences,
6. its ability to record information from both peripheral organs and its own environment.
So how these peculiarities of the brain’s energy demands are being satisfied by the entire organism and how do they influence the way organism works?

Researchers from University of Luebeck and Universite de Lausanne proposed a new framework for describing the regulation of energy flow in the organism. In the article “The selfish brain: competition for energy resources” they wrote:

“The brain prioritizes adjustment of its own ATP concentration. For this reason it activates its stress system and in so doing competes for energy resources with the rest of the organism (allocation). The brain then alters the appetite (food intake) so that it can alleviate the stress system and return it to a state of rest.”

Important points of the process of restoration of homeostatic balancing of energy supply are the following:

  1. When there’s a shortage of of glucose-based energy supply in the body, glucose allocation to the brain is provided anyway, even if the rest of the body is energy-starving.
  2. Alternative substrates than can provide a portion of the brains energy supply, such as ketones, lead to a “disburdening” of the regulatory system.
  3. This “disburdening” of the regulatory system works through ketogenesis, to ensure which the lipolysis starts leading to body mass reduction.
  4. Replenishment of the stores can be later possible due to glucose allocation to the muscle and adipose tissue leading to normalization of body mass.
  5. Return of the system of glucose sensors (in hypothalamus) in the brain to a state of balance (setpoint).


 

 

 

 

Source: Neuroscience and Biobehavioral Reviews 28 (2004) 143-180

To leave a comment or question click here